Name | Azamethiphos |
Synonyms | azametifos Azamethiphos Ciba-Geigy 18809 Oxazolo(4,5-b)pyridine, phosphorothioic acid deriv. S-(6-chloro-oxazolo[4,5-b]pyridin-2(3H)-on-3-ylmethyl) O,O-dimethyl phosphorothioate S-[(6-chloro-2-oxo[1,3]oxazolo[4,5-b]pyridin-3(2H)-yl)methyl] O,O-dimethyl phosphorothioate |
CAS | 35575-96-3 |
EINECS | 252-626-0 |
InChI | InChI=1/C9H10ClN2O5PS/c1-15-18(14,16-2)19-5-12-8-7(17-9(12)13)3-6(10)4-11-8/h3-4H,5H2,1-2H3 |
Molecular Formula | C9H10ClN2O5PS |
Molar Mass | 324.68 |
Density | 1.566g/cm3 |
Melting Point | 88-93°C |
Boling Point | 428.8°C at 760 mmHg |
Flash Point | 213.1°C |
Water Solubility | 1100 mg l-1 (20 °C) |
Vapor Presure | 1.48E-07mmHg at 25°C |
Storage Condition | 2-8℃ |
Refractive Index | 1.588 |
Physical and Chemical Properties | The pure chemical property is colorless crystal. M. p.89 ℃, vapor pressure 0.0049 × 10-3Pa (20 ℃), solubility at 20 ℃: benzene 13g/L, methanol 10 g/kg, dichloromethane 6.1 g/kg, water 1.1 g/kg. The half-life of hydrolysis reaction at 20 ℃ is 800h (pH 5), 260h (pH 7) and 4.3h (pH 8). |
Use | Can effectively kill flies, ants, cockroaches and other pests |
Hazard Symbols | Xn - Harmful |
Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
UN IDs | UN 1593 6.1/PG 3 |
Raw Materials | Sulfur(α) Chlorine Dimethyl hydrogen phosphite |
Vapor pressure | 4.9 x 10-6 Pa (20 °C) |
storage conditions | Sealed in dry,2-8°C |
water solubility | 1100 mg l-1 (20 °C) |
morphology | Solid |
acidity coefficient (pKa) | 0.94±0.20(Predicted) |
NIST chemical information | Phosphorothioic acid, s-[(6-chloro-2-oxooxazolo[4,5-b]pyridin-3(2h)-yl)methyl] o,o-dimethyl ester(35575-96-3) |
EPA chemical information | Azamethiphos (35575-96-3) |
WGK Germany | 3 |
RTECS number | TE8070000 |
customs code | 29349990 |
Toxicity | LD50 orl-rat: 1180 mg/kg PEMNDP 9,44,91 |
symptoms of poisoning
Mild poisoning: headache, dizziness, nausea, vomiting, sweating, weakness, chest tightness, blurred vision, poor appetite, etc. Whole blood cholinesterase generally drops below 70% of normal value. Moderate poisoning: In addition to the above symptoms, there are also mild dyspnea, muscle tremor, miosis, trance, unstable walking, salivation, abdominal pain, diarrhea, etc. In severe cases, coma, convulsions, dyspnea, foaming at the mouth, incontinence, convulsions, and respiratory paralysis will also occur. Acute poisoning usually occurs within 12 hours, and those who take it by mistake can develop it immediately.
emergency treatment
[1] use atropine 1~5mg subcutaneously or intravenously (depending on the severity of poisoning) [2] use pyridine 0.4-1.2g intravenously (depending on the severity of poisoning) [3] disable morphine, teabine, phenothiazine and reserpine. [4] Immediately induce vomiting, gastric lavage, and catharsis (vomiting can only be induced when awake).
precautions
can be mixed with other pesticides
organophosphorus insecticides
P> Zolidinophosphate is also called methyl pyridinophosphate. It is an organophosphorus insecticide. It is a white or white-like crystalline powder. It has an odor and is slightly soluble in water. Soluble in organic solvents such as methanol and dichloromethane. Used to kill blood-sucking insects such as livestock and flies in poultry houses. This product is added with exogenous fly attractant, which has a trapping effect on flies and can be used for spraying or coating.this product is a new organophosphorus pesticide with high efficiency and low toxicity. Mainly stomach poison, and has the effect of contact killing, killing flies, cockroaches, ants and adults of some insects. Because these insect adults have the habit of licking, drugs that work through stomach poison are more effective. If combined with the inducer, it can increase the ability to induce flies by 2 to 3 times. According to the specified concentration of one-time spray, the reduction rate of flies can reach 84% ~ 97%. Methylpyridinophosphate also has the characteristics of long residual period. Apply it on cardboard, hang it in the house or stick it on the wall, the residual effect period can reach 10-12 weeks, and the residual effect period can reach 6-8 weeks when sprayed on the wall ceiling.
Animals are almost completely absorbed after eating zolidinophosphate. After 12 hours of oral administration of goats, the drug is excreted 76% in urine, 5% in feces and 0.5% in milk. The residue in tissue was low, 0.022 mg/kg for muscle and 0.14-0.4 mg/kg for kidney. Hens took 5 mg/kg of medicated feed, and the residual amount after 22 hours was 0.1 mg/kg for blood and 0.6 mg/kg for kidney. It can be seen that the drug has very little residue in meat, fat and eggs, and there is no need to specify the withdrawal period. In addition to adult flies, this product also has a good killing effect on cockroaches, ants, fleas, bedbugs, etc. It is mainly used to kill adult flies in stables and chicken houses; it is also used to kill flies and cockroaches in rooms, restaurants, food factories and other places.
Toxicity
the acute oral LD50 of rats is 1180mg/kg, and the acute percutaneous LD50 of rats is> 2150mg/kg. It has mild irritation to rabbit eyes and no irritation to skin. The 90-day feeding test of rats showed that the non-effective dose was 20 mg/kg feed and that of dogs was 10 mg/kg (0.3 mg/kg per day). Rainbow trout LC50 is 0.2mg/L, carp LC50 is 6.0 mg/kg, green gill fish LC50 is 8.0mg/L (both 96h), low toxicity to birds, toxic to bees.
use
1, insecticide, acaricide. It has the effects of contact and stomach poison, and has good effect. The pesticide has a wide spectrum of insecticides and can be used to control various mites and moths, aphids, leafhoppers, wood lice, small heart eating insects, potato beetles and cockroaches in cotton, fruit trees, vegetable fields and livestock, families and public places. Use a dose of 0.56~1.12kg/hm2.
2. Zolidinophosphate is an organophosphorus compound that is synergistic to kill insects and mites. Can effectively kill flies, ants, cockroaches and other pests.
production method
preparation of N-hydroxymethyloxazolo [4,5-b] pyridine -3-(2H) ketone 109g oxazolo [4,5-b] pyridine -3-(2H) ketone and 37% formaldehyde aqueous solution were hydroxymethylated at 50~60 ℃ to obtain 126g N-hydroxymethyloxazolo [4,5-b] pyridine-3-(2H) ketone.
Preparation of N-chloromethyl oxazolo [4,5-b] pyridine -3-(2H) ketone The N-hydroxymethyl oxazolo [4,5-b] pyridine -3-(2H) ketone prepared by the previous step is chlorinated with thionyl chloride at 60°C to prepare N-chloromethyl oxazolo [4,5-b] pyridine-3-(2H) ketone 125g.
Synthesis of methylpyridamp The N-chloromethyloxazolo [4,5-b] pyridine -3-(2H) ketone prepared in the previous step is combined with O,O-dimethylthiophosphate ammonium salt [(CH3O)2P(O)SNH4] to prepare methylpyridamp.
category
Pesticides
toxicity classification
Poisoning
acute toxicity
oral-rat LD50; 1180 mg/kg; skin-rat LD50: 2150 mg/kg
flammability hazard characteristics
Combustible; combustion produces toxic nitrogen oxides, sulfur oxides, phosphorus oxides and chloride smog
storage and transportation features
Ventilated low temperature drying
fire extinguishing agent
Dry powder, foam, sand, carbon dioxide, mist water